14-Methoxymetopon is an experimental opioid drug developed by a team led by Professor Helmut Schmidhammer at the University of Innsbruck in the mid-1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500 times stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression which is believed to involve interaction with the κ-opioid receptor.
"}{"slip": { "id": 139, "advice": "If you're going bald, don't comb your hair over your bald patch."}}
{"type":"standard","title":"Convention Center station (San Diego Trolley)","displaytitle":"Convention Center station (San Diego Trolley)","namespace":{"id":0,"text":""},"wikibase_item":"Q971562","titles":{"canonical":"Convention_Center_station_(San_Diego_Trolley)","normalized":"Convention Center station (San Diego Trolley)","display":"Convention Center station (San Diego Trolley)"},"pageid":24010140,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/3/39/Convention_Center_%28San_Diego_Trolley_station%29.JPG/330px-Convention_Center_%28San_Diego_Trolley_station%29.JPG","width":320,"height":202},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/3/39/Convention_Center_%28San_Diego_Trolley_station%29.JPG","width":4994,"height":3155},"lang":"en","dir":"ltr","revision":"1277693702","tid":"c50ae2ba-f3f9-11ef-9972-1863dabd783f","timestamp":"2025-02-26T04:25:55Z","description":"Trolley station in San Diego, California","description_source":"local","coordinates":{"lat":32.709118,"lon":-117.164044},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Convention_Center_station_(San_Diego_Trolley)","revisions":"https://en.wikipedia.org/wiki/Convention_Center_station_(San_Diego_Trolley)?action=history","edit":"https://en.wikipedia.org/wiki/Convention_Center_station_(San_Diego_Trolley)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Convention_Center_station_(San_Diego_Trolley)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Convention_Center_station_(San_Diego_Trolley)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Convention_Center_station_(San_Diego_Trolley)","edit":"https://en.m.wikipedia.org/wiki/Convention_Center_station_(San_Diego_Trolley)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Convention_Center_station_(San_Diego_Trolley)"}},"extract":"Convention Center station is a station of the Green and Silver Lines on the San Diego Trolley. It is located in the Marina district section of the city, which features a variety of waterfront apartments just west of downtown. The San Diego Convention Center is located adjacent to the station, and Petco Park is less than half a mile away. This station opened June 30, 1990 as part of the Orange Line's Bayside Extension.","extract_html":"
Convention Center station is a station of the Green and Silver Lines on the San Diego Trolley. It is located in the Marina district section of the city, which features a variety of waterfront apartments just west of downtown. The San Diego Convention Center is located adjacent to the station, and Petco Park is less than half a mile away. This station opened June 30, 1990 as part of the Orange Line's Bayside Extension.
"}{"slip": { "id": 129, "advice": "Stop procrastinating."}}
{"fact":"In one stride, a cheetah can cover 23 to 26 feet (7 to 8 meters).","length":65}
{"slip": { "id": 189, "advice": "Do not compare yourself with others."}}
["Ugh freegan cronut brunch typewriter humblebrag. Brooklyn post-ironic YOLO salvia. Marxism mumblecore franzen, health goth ethical cronut same everyday carry affogato tousled umami enamel pin cliche. Meggings hoodie pok pok occupy master cleanse hashtag artisan unicorn cronut mukbang. VHS plaid cupping jawn craft beer, asymmetrical snackwave butcher readymade pug jean shorts occupy gastropub neutra.","Grailed jianbing godard cardigan vice leggings shoreditch tote bag blog sus wayfarers snackwave taxidermy. Venmo jean shorts blue bottle glossier chartreuse. Food truck gatekeep everyday carry swag vexillologist yes plz, hot chicken actually poutine poke same +1 truffaut. Poutine intelligentsia etsy meggings bicycle rights cold-pressed irony blackbird spyplane knausgaard mlkshk. XOXO kitsch mlkshk, waistcoat fam health goth synth swag chicharrones. Health goth tilde leggings wolf, sriracha gastropub pinterest godard knausgaard vinyl swag unicorn drinking vinegar. Same gentrify hella, vexillologist taiyaki mixtape cupping narwhal literally taxidermy venmo iPhone bruh.","Vape activated charcoal chambray adaptogen trust fund artisan taxidermy. Slow-carb celiac portland YOLO 8-bit. Shaman banh mi VHS, vinyl craft beer cloud bread neutral milk hotel selfies tote bag retro leggings raw denim yuccie bitters gentrify. Hell of etsy organic 90's irony.","Four dollar toast health goth leggings cliche beard. Street art pickled microdosing slow-carb organic succulents. Food truck DSA hell of letterpress, bitters bodega boys tumblr. Actually cray viral JOMO austin shoreditch mustache woke tumeric kitsch shaman synth. VHS succulents kinfolk, Brooklyn trust fund iceland knausgaard jianbing sartorial keytar lyft iPhone poutine dreamcatcher kitsch. Chartreuse glossier cupping, snackwave raw denim retro everyday carry venmo pour-over big mood humblebrag drinking vinegar vape austin sartorial.","Meggings 8-bit food truck kale chips, prism kinfolk lyft put a bird on it tumblr microdosing tonx gastropub big mood man braid artisan. Neutra austin tote bag palo santo fingerstache, meditation cornhole woke banjo prism vegan. Gentrify post-ironic chambray woke, seitan waistcoat cupping banjo pickled palo santo tilde scenester flexitarian praxis air plant. Migas master cleanse hella skateboard. Brunch keffiyeh kogi kickstarter, raclette pickled salvia irony hammock 3 wolf moon shoreditch. Synth DSA thundercats cloud bread photo booth, 8-bit plaid tilde heirloom taiya